Molecular explorations

We use an interdisciplinary approach to elucidate the molecular mechanisms underlying fundamental cellular processes. Research designs incorporate structural biology, biophysics, biochemistry, and cell biology with a particular focus on protein structure-function studies.

Research

Biofilm formation

Bacteria are constantly challenged with changing environments, which can lead to more beneficial or more hostile conditions for the microbe. They react to these external cues - e.g. nutrients, changes in microbiome composition, antibiotics and host factors - by adjusting their physiological processes. One such process is biofilm formation, the regulated switch from a free-floating to a sessile, community lifestyle. Biofilms form on biotic and abiotic surfaces. They occur in natural, industrial, and hospital settings. We study the signal transduction pathways that control bacterial biofilm formation.

Membrane dynamics

We study the mechanisms that drive membrane fusion and fission in eukaryotes, fundamental cellular processes that are impaired in a group of neurological disorders. In particular, we investigate the structure and function of proteins that deform, tether, and fuse biological membranes.

Meet the Sondermann Lab

We recruit from the Graduate Fields of Biophysics, BBS, and BMCB.

Holger Sondermann

Professor 
PhD [CV]


John O'Donnell

Graduate Student 
BBS (Pharmacology)


Carolyn Kelly

Graduate Student
BMCB


Justin Lormand

Graduate Student
BMCB


Karin Eger

Undergraduate Researcher


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