Publication

Giacalone, D., Smith, T.J., Collins, A.J., Sondermann, H., Koziol, L.J., and O’Toole, G.A. (2018). Ligand-mediated biofilm formation via enhanced physical interaction between a diguanylate cyclase and its receptor. MBio 9: e01254-18.

Smith, J.T., Sondermann, H., and O’Toole, G.A. (2018). Type 1 does the two-step: Type 1 secretion substrates with a functional periplasmic intermediate. J Bacteriol (Pub ahead of print).

Dingemans, J., Poudyal, B., Sondermann, H., and Sauer, K. (2018). The Yin and Yang of SagS: Distinct residues in the HmsP domain of SagS independently regulate biofilm formation and biofilm drug tolerance. mSphere 3: e00192-18.

Smith, T.J., Font, M.E., Kelly, C.M., Sondermann, H., and O’Toole, G.A. (2018). An N-terminal retention module anchors the giant adhesin LapA of Pseudomonas fluorescens at the cell surface: A novel sub-family of type I secretion systems. J Bacteriol 200(8): e00734-17.

O’Donnell, J.P., March, H.M., Sondermann, H., and Sevier, C.S. (2018). Disrupted hydrogen bond network and impaired ATPase activity in an Hsc70 cysteine mutant. Biochemistry 57(7): 1073-1086.

O’Donnell, J.P., Byrnes, L.J., Cooley, R.B., and Sondermann, H. (2018). A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. J Biol Chem 293: 687-700.

O’Donnell, J.P., Cooley, R.B., Kelly, C.M., Miller, K., Andersen, O.S., Rusinova, R., and Sondermann, H. (2017). Timing and reset mechanism of GTP hydrolysis-driven conformational changes of atlastin. Structure 25(7): 997-1010. [Pubmed]

Cooley, R.B. and Sondermann, H. Probing protein-protein interactions with genetically encoded photo-activatable crosslinkers. Methods Mol Biol 1657: 331-345. [Pubmed]

Krasteva, P.V. and Sondermann H. (2017). Versatile modes of cellular regulation via cyclic dinucleotides. Nat Chem Biol 13(4): 350-359. [Pubmed]

Conner, J., Sondermann, H., Park, J.-H., Zamorano-Sánchez, D., and Yildiz, F. (2017). The ins and outs of cyclic di-GMP signaling in Vibrio cholerae. Curr Opin Microbiol 36: 20-29. [Pubmed]

Cooley, R.B., O'Donnell, J.P., and Sondermann, H. (2016). Coincidence detection and bi-directional transmembrane signaling control a bacterial second messenger receptor. Elife 5. pii: e21848. [Pubmed]

Dahlstrom, K.M., Giglio, K.M., Sondermann, H., and O’Toole, G.A. (2016). The inhibitory site of a diguanylate cyclase is a necessary element for interaction and signaling with an effector protein. J Bacteriol 198(11): 1595-1603. [Pubmed]

Meyer, P. Socias, S., Key, J. , Ransey, E. , Tjon, E.C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J. , Neau, D.B., Rajashankar, K., Anderson, K.S., Baxter, R. , Blacklow, S., Boggon, T., Bonvin, A., Borek, D., Brett, T., Caflisch, A. , Chang, C.I. , Chazin, W., Corbett, K.D. , Cosgrove, M., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C., Eck, M., Eichman, B., Fan, Q., Ferré-D'Amaré, A., Fraser, J.S., Fromme, J.C., Garcia, K., Gaudet, R., Gong, P., Harrison, S., Heldwein, E., Jia, Z., Keenan, R., Kruse, A. , Kvansakul, M., McLellan, J., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E.F., Pereira, P.J.B., Petosa, C., Raman, C.S., Rapoport, T., Roll-Mecak, A., Rosen, M., Rudenko, G., Schlessinger, J., Schwartz, T., Shamoo, Y., Sondermann, H., Tao, Y., Tolia, N., Tsodikov, O.V., Westover, K.D., Wu, H., Foster, I. , Maia, F., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M., and Sliz, P. (2016). Data publication with the structural biology data grid supports live analysis. Nat Commun 7: 10882. [Pubmed]

Matsuyama, B.Y., Krasteva. P.V., Baraquet, C., Harwood, C.S., Sondermann, H., and Navarro, M.V.A.S. (2016). Mechanistic insights into c-di-GMP-dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa. Proc Natl Acad Sci USA 113(2): E209-218. [Pubmed]

Dahlstrom, K.M., Giglio, K.M., Collins, A.J., Sondermann, H., and O’Toole, G.A. (2015). Contribution of physical interactions to signaling specificity between a diguanylate cyclase and its effector. mBio 6(6): e01978-15. [Pubmed]

Cooley, R.B., Smith, T.J., Leung, W., Tierney, V., Borlee, R.B., O’Toole, G.A., and Sondermann, H. (2015). Second messenger regulation of cell-cell adhesion in Pseudomonas aeruginosa. J Bacteriol 198(1): 66-67. [Pubmed]
• Featured in Parsek, M.R., (2015). Controlling the connections of cells to the biofilm matrix. J Bacteriol 198(1): 12-14.

Chatterjee, D., Cooley, R.B., Boyd, C.D., Mehl, R.A., O'Toole, G.A., and Sondermann, H. (2014). Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP. Elife 3: e03650. [Pubmed]

Gao, L., Giglio, K.M., Nelson, J.L., Sondermann, H., Travis, A.J. (2014). Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination. Nanoscale 6(5): 2588-2593. [Pubmed]

McNew, J.A., Sondermann, H., Lee, T., Stern, M., and Brandizzi, F. (2013). GTP-dependent membrane fusion. Annu Rev Cell Dev Biol 29: 529-550. [Pubmed]

Giglio, K.M., Fong, J.C., Yildiz, F.H., and Sondermann, H. (2013). Structural basis for biofilm formation via the Vibrio cholerae matrix protein RbmA. J Bacteriol 195(14): 3277-3286. [Pubmed]

Byrnes, L.J., Singh, A., Szeto, K., Benvin, N.M., O’Donnell, J.P., Zipfel, W.R., and Sondermann, H. (2013). Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J 32(3): 369-384. [Pubmed]
• Highlighted by the Faculty of 1000.

Goh, S.L., Wang, Q., Byrnes, L.J., and Sondermann, H. (2012). Versatile membrane deformation potential of activated pacsin. PLoS One 7(12): e51628. [Pubmed]

Boyd, C.D., Chatterjee, D., Sondermann, H., and O’Toole, G.A. (2012). LapG, required for modulating biofilm formation by Pseudomonas fluorescens Pf0-1, is a calcium-dependent protease. J Bacteriol 194(16): 4406-4414. [Pubmed]

Chatterjee, D., Boyd, C.D., O’Toole, G.A., and Sondermann, H. (2012). Structural evidence for a conserved, calcium-dependent mechanism of the periplasmic DUF920-like protease LapG from Legionella pneumophila. J Bacteriol 194(16): 4415-4425. [Pubmed]

Krasteva, P.V., Giglio, K.M., and Sondermann, H. (2012). Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP. Protein Sci 21(7): 929-948. [Pubmed]

Rozovsky, S., Forstner, M., Sondermann, H., and Groves, J.T. (2012). Single molecule kinetics of ENTH binding to lipid membranes. J Phys Chem B 116(17): 5122-5131. [Pubmed]

Sondermann, H., Shikuma, N.J., and Yildiz, F.H. (2012). You've come a long way: c-di-GMP signaling. Curr Opin Microbiol 15(2): 140-146. [Pubmed]

Wang, Q., Byrnes, L.J., Shui, B., Röhrig, U.F., Singh, A., Chudakov, D.M., Lukyanov, S.A., Zipfel, W.R., Kotlikoff, M.I., and Sondermann, H. (2011). Molecular mechanism of a green-shifted variant of the red-fluoresent protein mKate. PLoS One 6(8): e23513. [Pubmed]

Forster, B., Bitar, A.P., Slepkov, E., Kota, K., Sondermann, H., and Marquis, H. (2011). The metalloprotease of Listeria monocytogenes is regulated by pH. J Bacteriol 193(19): 5090-5097. [Pubmed]

Shui, B, Wang, Q, Byrnes, L.J., Lee, F., Chudakov, D.M., Lukyanov, S.A., Sondermann,H., and Kotlikoff, M.I. (2011). Circular permutation of red fluorescent proteins. PLoS One 6(5): e20505. [Pubmed]

Byrnes, L.J., and Sondermann, H. (2011). From the Cover: Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A. Proc Natl Acad Sci USA 108(6): 2216-2221. [Pubmed]
• Featured in Daumke, O., and Praefcke, G.J.K. (2011). Structural insights into membrane fusion at the endoplasmic reticulum. Proc Natl Acad Sci USA 108(6): 2175-2176.
• Highlighted by the Faculty of 1000 as “Must Read”.

Navarro, M.V.A.S., Newell, P.D., Krasteva, P.V., Chatterjee, D., Madden, D.R., O’Toole, G.A., and Sondermann, H. (2011). Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biology 9(2): e1000588. [Pubmed]
• Highlighted by the Faculty of 1000 as “Recommended”.

Newell, P.D., Boyd, C., Sondermann, H., and O’Toole, G.A. (2011). A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. PLoS Biology 9(2): e1000587. [Pubmed]
• Highlighted by the Faculty of 1000 as “Recommended” and “Must Read”.

De, N., Navarro, M.V.A.S., Wang, Q., Krasteva, P.V., and Sondermann, H. (2010). Biophysical assays for protein interactions in the Wsp sensory system and biofilm formation. Methods in Enzymology 471: 161-84. [Pubmed]

Krasteva, P.V., Fong, J.C.N., Shikuma, N.J., Beyhan, S., Navarro, M.V.A.S., Yildiz, F.H., and Sondermann, H. (2010). Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science 327: 866-868. [Pubmed]
• Featured in Riddihough, G. (2010). Decoding a Second Messenger’s Message. Sci Signal 3, ec56.
• Highlighted by the Faculty of 1000 as “Recommended”.

De, N., Navarro, M.V.A.S., Raghavan, R.V., and Sondermann, H. (2009). Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR. J Mol Biol 393(3): 619-633. [Pubmed]

Navarro, M.V.A.S., De, N., Bae, N., Wang, Q., and Sondermann, H. (2009). Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure 17(8): 1104-1116. [Pubmed]
• Highlighted by the Faculty of 1000 as “Recommended”.

Wang, Q., Navarro, M.V.A.S., Peng, G., Molinelli, E., Goh, S.L., Judson, B.L., Rajashankar, K.R., and Sondermann, H. (2009). Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc Natl Acad Sci USA 106(31): 12700-12705. [Pubmed]

Ahmed, A.H., Thompson, M., Fenwick, M., Romero, B., Loh, A., Jane, D., Sondermann H., and Oswald, R.E. (2009). Mechanisms of antagonism of the GluR2 AMPA receptor: Structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry 48(18): 3894-3903. [Pubmed]

Wang, Q., Shui, B., Kotlikoff, M.I., and Sondermann, H. (2008). Structural basis for calcium sensing by GCaMP2. Structure 16(12): 1817-1827. [Pubmed]

Ahmed, A.H., Wang, Q., Sondermann H., and Oswald, R.E. (2008). Structure of the S1S2 glutamate binding domain of GluR3. Proteins 75(3): 628-637. [Pubmed]

Wang, Q., Kaan, H.Y.K., Hooda, R.N., Goh, S.L., and Sondermann, H. (2008). Structure and plasticity of Endophilin and Sorting Nexin 9. Structure 16(10): 1574-1587. [Pubmed]

De, N., Pirruccello, M., Krasteva, P.V., Bae, N., Raghavan, R.V., and Sondermann, H. (2008). Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biology, 6(3): e67. [Pubmed]


Research as a postdoctoral fellow:

Gureasko, J., Kuchment, O., Makino, D., Sondermann, H., Bar-Sagi, D. and Kuriyan, J. (2010). The role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci USA 107: 3430-3435. [Pubmed]

Freedman, T.S., Sondermann, H., Kuchment, O., Friedland, G.D., Kortemme, T., and Kuriyan, J. (2009). Differences in flexibility underlie functional differences in the Ras activators Son of sevenless and Ras Guanine Nucleotide Releasing Factor 1. Structure 17(1): 41-53. [Pubmed]

Gureasko, J., Galush, W., Boykevisch, S., Sondermann, H., Bar-Sagi, D., Groves, J., and Kuriyan, J. (2008). Membrane-dependent signal integration of the Ras activator Son of Sevenless. Nat Struct Mol Biol 15(5): 452-461. [Pubmed]

Freedman, T.S., Sondermann, H., Friedland, G., Kortemme, T., Bar-Sagi, D., Marqusee, S., and Kuriyan, J. (2006). A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci USA 103(45): 16692-16697. [Pubmed]

Boykevisch, S., Zhao, C., Sondermann, H., Philippidou, P., Halegoua, S., Kuriyan, J., and Bar-Sagi, D. (2006). Regulation of Ras signaling dynamics by Sos-mediated positive feedback. Current Biology 16(21): 2173-2179. [Pubmed]

Pirruccello, M., Sondermann, H., Pelton, J.G., Pellicena, P., Hoelz, A., Chernoff, J., Wemmer, D.E., and Kuriyan, J. (2006). A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol 361(2): 312-326. [Pubmed]

Sondermann, H., Nagar, B., Bar-Sagi, D., and Kuriyan, J. (2005). Computational docking and solution X-ray scattering predict a membrane-interacting role for the histone domain of the Ras-activator Son of Sevenless. Proc Natl Acad Sci USA 102(46): 16632-16637. [Pubmed]

Sondermann, H., and Kuriyan, J. (2005). C2 can do it, too. Cell 12(2)1: 158-160. [Pubmed

Mao, X., Ren, Z., Parker, G.N., Sondermann, H., Pastorello, M.A., Wang, W., McMurray, J.S., Demeler, B., Darnell, J.E.Jr., and Chen, X. (2005). Structural bases of unphosphorylated STAT1 association and receptor binding. Molecular Cell 17(6): 761-771. [Pubmed]

Sondermann, H., Zhao, C., and Bar-Sagi, D. (2005). Analysis of Ras:RasGEF Interactions by Phage Display and Static Multi Angle Light Scattering. Methods 37(2): 197-202. [Pubmed]

Sondermann, H., Soisson, S.M., Boykevisch, S., Yang, S.-S., Bar-Sagi, D., and Kuriyan, J. (2004). Structural analysis of autoinhibition in the Ras activator Son of Sevenless. Cell 119(3): 393-405. [Pubmed]

Sondermann, H., Soisson, S.M., Bar-Sagi, D., and Kuriyan, J. (2003). Tandem histone folds in the structure of the N-terminal segment of the Ras activator Son of Sevenless. Structure 11(12): 1583-1593. [Pubmed]

Margarit, S.M., Sondermann, H., Hall, B.E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D. and Kuriyan, J. (2003). Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112(5): 685-695. [Pubmed]


Research as a graduate student:

Harkiolaki, M., Lewitzky, M., Jones, E.Y., Bourette, R., Mouchiroud, G., Sondermann, H., Moarefi, I. and Feller, S.M. (2003). Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76. EMBO J 22(11): 2571-2582. [Pubmed]

Sondermann, H., Ho, A.K., Listenberger, L.L., Siegers, K., Moarefi, I., Wente, S.R., Hartl, F.U. and Young, J.C. (2002). Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in S. cerevisiae. J Biol Chem 277(36): 33220-33227. [Pubmed]

Sondermann, H., Scheufler, C., Schneider, C., Hohfeld, J., Hartl, F.U. and Moarefi, I. (2001). Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science 291(5508): 1553-1557. [Pubmed]

Sondermann, H., Becker, T., Mayhew, M., Wieland, F. and Hartl, F.U. (2000). Characterization of a receptor for heat shock protein 70 on macrophages and monocytes. Biol Chem 381(12): 1165-1174. [Pubmed]

Obermann, W.M., Sondermann, H., Russo, A.A., Pavletich, N.P. and Hartl, F.U. (1998). In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol 143(4): 901-910. [Pubmed]


Research as an undergraduate student:

El Mourabit, H., Poinat, P., Koster, J., Sondermann, H., Wixler, V., Wegener, E., Laplantine, E., Geerts, D., Georges-Labouesse, E., Sonnenberg, A. and Aumailley, M. (2002). The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin α5 and α6 subunits. Matrix Biol 21(2): 207-214. [Pubmed]

Sondermann, H., Dogic, D., Pesch, M. and Aumailley, M. (1999). Targeting of cytoskeletal linker proteins to focal adhesion complexes is reduced in fibroblasts adhering to laminin-1 when compared to fibronectin. Cell Adhes Commun 7(1): 43-56. [Pubmed]

[Link to Pubmed bibliography]